Saving Lives With Hemostatic Medicine.
A numb commonly reach-me-down to prevent excess bleeding in surgeries could keep thousands of people from bleeding to death after trauma, a recent study suggests. The drug, tranexamic acid (TXA) is cheap, by many available around the world and easily administered. It works by significantly reducing the rate at which blood clots foil down, the researchers explained natural. "When people have serious injuries, whether from accidents or violence, and when they have stiff hemorrhage they can bleed to death.
This treatment reduces the chances of bleeding to death by about a sixth," said researcher Dr Ian Roberts, a professor of epidemiology at the London School of Hygiene and Tropical Medicine in the UK. According to Roberts, each year about 600000 woman in the street bleed to extermination worldwide saw palmetto india. "So, if you could minimize that by a sixth, you've saved 100000 lives in one year".
The report, which was mainly funded by philanthropic groups and the British government, is published in the June 15 online version of The Lancet. For the study, Roberts and colleagues in the CRASH-2 consortium randomly assigned more than 20000 trauma patients from 274 hospitals across 40 countries to injections of either TXA or placebo.
Among patients receiving TXA, the rebuke of ruin from any cause was cut by 10 percent compared to patients receiving placebo, the researchers found. In the TXA group, 14,5 percent of the patients died compared with 16 percent of the patients in the placebo group.
Showing posts with label bleeding. Show all posts
Showing posts with label bleeding. Show all posts
Tuesday, March 12, 2019
Thursday, March 1, 2018
To Protect From Paralysis Associated With Spinal Cord Injuries Can Oriented On Genes Therapy
To Protect From Paralysis Associated With Spinal Cord Injuries Can Oriented On Genes Therapy.
A cram in rats is raising creative want for a treatment that might help spare people with injured spines from the paralysis that often follows such trauma. Researchers found that by without delay giving injured rats a drug that acts on a specific gene, they could halt the unsafe bleeding that occurs at the site of spinal damage erectile dysfunction. That's important, because this bleeding is often a major cause of paralysis linked to spinal rope injury, the researchers say.
In spinal cord injury, fractured or dislocated bone can repress or damage axons, the long branches of nerve cells that transmit messages from the body to the brain herbalms.com. But post-injury bleeding at the site, called increasing hemorrhagic necrosis, can create these injuries worse, explained study author Dr J Marc Simard, a professor of neurosurgery, pathology and physiology at University of Maryland School of Medicine in Baltimore.
Researchers have elongate been searching for ways to deal with this supportive injury. In the study, Simard and his colleagues gave a drug called antisense oligodeoxynucleotide (ODN) to rodents with spinal line injuries for 24 hours after the injury occurred. ODN is a predetermined single strand of DNA that temporarily blocks genes from being activated. In this case, the benumb suppresses the Sur1 protein, which is activated by the Abcc8 gene after injury.
After programmed injuries, Sur1 is usually a beneficial part of the body's defense mechanism, preventing chamber death due to an influx of calcium, the researchers explained. However, in the case of spinal cord injury, this defense process goes awry. As Sur1 attempts to prevent an influx of calcium into cells, it allows sodium in and too much sodium can cause the cells to swell, short-circuit up and die.
In that sense, "the 'protective' structure is a two-edged sword. What is a very good thing under conditions of moderate injury, under critical injury becomes a maladaptive mechanism and allows unchecked sodium to come in, causing the room to literally explode".
However, the new gene-targeted therapy might put a stop to that. Injured rats given the deaden had lesions that were one-fourth to one-third the size of lesions in animals not given the drug. The animals also recovered from their injuries much better.
A cram in rats is raising creative want for a treatment that might help spare people with injured spines from the paralysis that often follows such trauma. Researchers found that by without delay giving injured rats a drug that acts on a specific gene, they could halt the unsafe bleeding that occurs at the site of spinal damage erectile dysfunction. That's important, because this bleeding is often a major cause of paralysis linked to spinal rope injury, the researchers say.
In spinal cord injury, fractured or dislocated bone can repress or damage axons, the long branches of nerve cells that transmit messages from the body to the brain herbalms.com. But post-injury bleeding at the site, called increasing hemorrhagic necrosis, can create these injuries worse, explained study author Dr J Marc Simard, a professor of neurosurgery, pathology and physiology at University of Maryland School of Medicine in Baltimore.
Researchers have elongate been searching for ways to deal with this supportive injury. In the study, Simard and his colleagues gave a drug called antisense oligodeoxynucleotide (ODN) to rodents with spinal line injuries for 24 hours after the injury occurred. ODN is a predetermined single strand of DNA that temporarily blocks genes from being activated. In this case, the benumb suppresses the Sur1 protein, which is activated by the Abcc8 gene after injury.
After programmed injuries, Sur1 is usually a beneficial part of the body's defense mechanism, preventing chamber death due to an influx of calcium, the researchers explained. However, in the case of spinal cord injury, this defense process goes awry. As Sur1 attempts to prevent an influx of calcium into cells, it allows sodium in and too much sodium can cause the cells to swell, short-circuit up and die.
In that sense, "the 'protective' structure is a two-edged sword. What is a very good thing under conditions of moderate injury, under critical injury becomes a maladaptive mechanism and allows unchecked sodium to come in, causing the room to literally explode".
However, the new gene-targeted therapy might put a stop to that. Injured rats given the deaden had lesions that were one-fourth to one-third the size of lesions in animals not given the drug. The animals also recovered from their injuries much better.
Tuesday, August 11, 2015
The Aspirin For Preventing Cardiovascular Disease
The Aspirin For Preventing Cardiovascular Disease.
Many Americans are acceptable using diurnal low-dose aspirin inappropriately in the hopes of preventing a first-time heart attack or stroke, a young study suggests. Researchers found that of nearly 69000 US adults prescribed aspirin long-term, about 12 percent unquestionably should not have been. That's because their odds of suffering a heart attack or happening were not high enough to outweigh the risks of daily aspirin use, said Dr Ravi Hira, the leadership researcher on the study and a cardiologist at Baylor College of Medicine in Houston sleepingaids. Experts have crave known that for people who've already had a heart attack or stroke, a daily low-dose aspirin can settle the risk of suffering those conditions again.
Things get more complicated, though, when it comes to preventing a first-time humanitarianism attack or stroke - what doctors call "primary prevention". In general, the benefits of aspirin remedy are smaller, and for many people may not justify the downsides. "Aspirin is not a medication that comes without risks" the best pro med. He illustrious the drug can cause serious gastrointestinal bleeding or hemorrhagic stroke (bleeding in the brain).
Still, common people sometimes dismiss the bleeding risks partly because aspirin is so familiar and readily available. The fantasy of protecting the heart by simply taking a pill might appeal to some people. "It's all things considered easier to take a pill than to change your lifestyle," Hira pointed out. But based on the budding findings, many Americans may be making the wrong choice, Hira's team reported Jan. 12 online in the Journal of the American College of Cardiology.
The results are based on medical records for more than 68800 patients at 119 cardiology practices across the United States. The heap included bodies with record blood pressure who had not yet developed heart disease. Overall, Hira's line-up found, almost 12 percent of patients seemed to be prescribed aspirin unnecessarily - their risks of empathy trouble or stroke were not high enough to justify the risks of long-term aspirin use.
Many Americans are acceptable using diurnal low-dose aspirin inappropriately in the hopes of preventing a first-time heart attack or stroke, a young study suggests. Researchers found that of nearly 69000 US adults prescribed aspirin long-term, about 12 percent unquestionably should not have been. That's because their odds of suffering a heart attack or happening were not high enough to outweigh the risks of daily aspirin use, said Dr Ravi Hira, the leadership researcher on the study and a cardiologist at Baylor College of Medicine in Houston sleepingaids. Experts have crave known that for people who've already had a heart attack or stroke, a daily low-dose aspirin can settle the risk of suffering those conditions again.
Things get more complicated, though, when it comes to preventing a first-time humanitarianism attack or stroke - what doctors call "primary prevention". In general, the benefits of aspirin remedy are smaller, and for many people may not justify the downsides. "Aspirin is not a medication that comes without risks" the best pro med. He illustrious the drug can cause serious gastrointestinal bleeding or hemorrhagic stroke (bleeding in the brain).
Still, common people sometimes dismiss the bleeding risks partly because aspirin is so familiar and readily available. The fantasy of protecting the heart by simply taking a pill might appeal to some people. "It's all things considered easier to take a pill than to change your lifestyle," Hira pointed out. But based on the budding findings, many Americans may be making the wrong choice, Hira's team reported Jan. 12 online in the Journal of the American College of Cardiology.
The results are based on medical records for more than 68800 patients at 119 cardiology practices across the United States. The heap included bodies with record blood pressure who had not yet developed heart disease. Overall, Hira's line-up found, almost 12 percent of patients seemed to be prescribed aspirin unnecessarily - their risks of empathy trouble or stroke were not high enough to justify the risks of long-term aspirin use.
Saturday, May 3, 2014
Intrauterine Spiral Can Reduce The Severity Of Menstrual Bleeding
Intrauterine Spiral Can Reduce The Severity Of Menstrual Bleeding.
Women with overcast menstrual bleeding may mark some relief using an intrauterine device, or IUD, containing the hormone levonorgestrel, according to budding research. British researchers found that the treated IUD was more effective at reducing the crap of heavy menstrual bleeding (also called menorrhagia) on quality of life compared to other treatments accutane testosterone level. Normally hand-me-down for contraception, the intrauterine system is sold under the brand name Mirena.
So "If women withstand with heavy periods and do not want to get pregnant - as the levonorgestrel intrauterine method is a contraceptive - then having the levonorgestrel intrauterine system is a very good first-line treatment privilege that does not require taking regular, daily oral medications," said the study's lead author, Dr Janesh Gupta, professor of obstetrics and gynecology at the University of Birmingham and Birmingham Women's Hospital in England mezotac tablet. For women who do want to get pregnant, Gupta said, taking the blood-clotting sedative tranexamic acid during periods is an deputy practice of treating heavy periods.
Results of the study, which was funded by the United Kingdom's National Institute of Health Research, appear in the Jan 10, 2013 distribution of the New England Journal of Medicine. Heavy menstrual bleeding is a significant muddle for many women. About 20 percent of gynecologist chore visits in the United States and the United Kingdom are because of heavy bleeding. There are several nonhormonal and hormonal healing options available to reduce blood loss.
The current swotting compared the use of traditional medical options - tranexamic acid pills, mefenamic acid (Ponstel), combined estrogen-progestogen and progesterone only - to the use of the levonorgestrel intrauterine system. The researchers randomly assigned nearly 600 women with broad menstrual bleeding to receive either the IUD or type medical care. They assessed improvement using a patient-reported score on a scale designed to technical gage severity of symptoms. The scale goes from 0 to 100, with lower scores indicating more inhuman symptoms.
Women with overcast menstrual bleeding may mark some relief using an intrauterine device, or IUD, containing the hormone levonorgestrel, according to budding research. British researchers found that the treated IUD was more effective at reducing the crap of heavy menstrual bleeding (also called menorrhagia) on quality of life compared to other treatments accutane testosterone level. Normally hand-me-down for contraception, the intrauterine system is sold under the brand name Mirena.
So "If women withstand with heavy periods and do not want to get pregnant - as the levonorgestrel intrauterine method is a contraceptive - then having the levonorgestrel intrauterine system is a very good first-line treatment privilege that does not require taking regular, daily oral medications," said the study's lead author, Dr Janesh Gupta, professor of obstetrics and gynecology at the University of Birmingham and Birmingham Women's Hospital in England mezotac tablet. For women who do want to get pregnant, Gupta said, taking the blood-clotting sedative tranexamic acid during periods is an deputy practice of treating heavy periods.
Results of the study, which was funded by the United Kingdom's National Institute of Health Research, appear in the Jan 10, 2013 distribution of the New England Journal of Medicine. Heavy menstrual bleeding is a significant muddle for many women. About 20 percent of gynecologist chore visits in the United States and the United Kingdom are because of heavy bleeding. There are several nonhormonal and hormonal healing options available to reduce blood loss.
The current swotting compared the use of traditional medical options - tranexamic acid pills, mefenamic acid (Ponstel), combined estrogen-progestogen and progesterone only - to the use of the levonorgestrel intrauterine system. The researchers randomly assigned nearly 600 women with broad menstrual bleeding to receive either the IUD or type medical care. They assessed improvement using a patient-reported score on a scale designed to technical gage severity of symptoms. The scale goes from 0 to 100, with lower scores indicating more inhuman symptoms.
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