Sulfonylurea Drugs Increase The Risk Of Heart Disease

Sulfonylurea Drugs Increase The Risk Of Heart Disease.
New explore shows that older hoi polloi with type 2 diabetes who take drugs known as sulfonylureas to cut their blood sugar levels may face a higher risk for heart problems than their counterparts who imagine metformin. Of the more than 8500 people aged 65 or older with kind 2 diabetes who were enrolled in the trial, 12,4 percent of those given a sulfonylurea drug experienced a soul attack or other cardiovascular event, compared with 10,4 percent of those who were started on metformin paurush jeevan capsule sex side effects. In addition, these sympathy problems occurred earlier in the course of treatment among those people taking the sulfonylurea drugs, the den showed.

The head-to-head comparison trial is slated to be presented Saturday at the American Diabetes Association annual conjunction in San Diego. Because the findings are being reported at a medical meeting, they should be considered precedence until published in a peer-reviewed journal enlargement. With type 2 diabetes, the body either does not manufacture enough of the hormone insulin or doesn't use the insulin it does produce properly.

In either case, the insulin can't do its job, which is to present glucose (blood sugar) to the body's cells. As a result, glucose builds up in the blood and can exercise havoc on the body. Metformin and sulfonylurea drugs - the latter a group of diabetes drugs including glyburide, glipizide, chlorpropamide, tolbutamide and tolazamide - are often centre of the first medications prescribed to lower blood sugar levels in people with type 2 diabetes.

The findings are important, the researchers noted, partly because sulfonylurea drugs are commonly prescribed among the senile to lower blood glucose levels. In addition, cardiovascular illness is the leading cause of death among people with type 2 diabetes. For several reasons, however, the budding study on these medications is far from the final word on the issue.

For one, people who are started on the sulfonylureas a substitute of metformin are often sicker to begin with, said Dr Spyros G Mezitis, an endocrinologist at Lenox Hill Hospital in New York City. Metformin cannot be prescribed to kin with constant kidney and heart problems. Both medications lower blood glucose levels, but go about it in solely different ways.

And "The sulfonylureas lower blood sugar by making the body produce more insulin, and this may cause small blood sugar or hypoglycemia". In contrast, metformin enhances the activity of the insulin that the body produces. Previous probing has shown that metformin is not linked with as high a risk of low blood sugar as the sulfonylureas.

Hypoglycemia robs the muscles - including those in the focus - of the glucose they need for energy, so they don't achievement as well. This is why these drugs may confer a higher risk for heart attack. The novel study, however, is based only on observations and does not prove any cause-and-effect relationship between these drugs and feeling problems.

Dr Jerome V Tolbert, medical director of the outreach team at the Friedman Diabetes Institute in New York City, urged circumspection in reacting to the new findings. "I wouldn't stake on this study and say, 'Everyone stop taking sulfonylureas,'" he said. But, "we are using less and less of these drugs because there are now newer and better drugs out there".

Some of the newer drugs are more costly. "If you are perturbed about your risks, cackle to your doctor for reassurance," he said, adding that people should never stop taking any prescribed medication without head talking to their doctor.

Dr Joel Zonszein, director of Clinical Diabetes Center at Montefiore Medical Center in New York City, agreed that the example findings are far from definitive. But, "we are using sulfonylureas less and less now view site. And we are only using them in very restricted patients and often for short periods of times to prescribe for high blood sugar, and then we switch to another drug".